Low-volume resuscitation using polyethylene glycol-20k in a preclinical porcine model of hemorrhagic shock
نویسندگان
چکیده
منابع مشابه
Low-Volume Resuscitation for Hemorrhagic Shock: Understanding the Mechanism of PEG-20k.
Hemorrhagic shock leads to cell and tissue swelling and no reflow from compressed capillaries. Cell impermeants, including polyethylene glycol-20,000 (PEG-20k), reverse ischemia-induced cell swelling, extend low-volume resuscitation (LVR) time after shock, and increase tolerance to the low-volume state. The purpose of this study was to explore the mechanisms of action of PEG-20k containing LVR ...
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An animal model was designed to study the effect of large volume Hypertonic Solutions (HTS) for resuscitation following a hypovolemic shock. Resuscitation in hypovolemic animals was performed by infusion of 15 ml/kg of normal saline (group I), 5% sodium bicarbonate (NaHCO3) (group II), 5% sodium chloride (NaCI) and 7.5 % NaHCO3 1:1 VN (group III), 5% NaC1 (group IV), and 5% NaCl and 5% serum a...
متن کاملVertebral Heart Score: A Useful Parameter in Determination of Resuscitation Endpoint in Dogs with Hemorrhagic Shock
BACKGROUND: GReliable prediction of patient response to fluid resuscitation is a crucial issue in the management of hemorrhagic shock. OBJECTIVES: This study was designed to investigate vertebral heart score (VHS) variation in fluid resuscitation of hemorrhagic shock patients and the feasibility of this method in determining resuscitation endpoint. METHODS: VHS values were assessed using previ...
متن کاملadministration of large volume hypertonic solutions for resuscitation of hemorrhagic shock in rabbit
an animal model was designed to study the effect of large volume hypertonic solutions (hts) for re suscitation following a hypovolemic shock. resuscitation in hypovolemic animals was performed by infusion of 15 ml/kg of normal saline (group i), 5% sodium bicarbonate (nahco3) (group ii), 5% sodium chloride (naci) and 7.5 % nahco3 1:1 vn (group iii), 5% nac1 (group iv), and 5% nacl and 5% serum a...
متن کاملInitial resuscitation of hemorrhagic shock
The primary treatment of hemorrhagic shock is control of the source of bleeding as soon as possible and fluid replacement. In controlled hemorrhagic shock (CHS) where the source of bleeding has been occluded fluid replacement is aimed toward normalization of hemodynamic parameters. In uncontrolled hemorrhagic shock (UCHS) in which bleeding has temporarily stopped because of hypotension, vasocon...
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ژورنال
عنوان ژورنال: Journal of Trauma and Acute Care Surgery
سال: 2016
ISSN: 2163-0755
DOI: 10.1097/ta.0000000000001155